Serum Peptidyl-prolyl Cis-trans Isomerase NIMA-interacted 1 (Pin1) as a Non-invasive Marker for Liver Fibrosis due to Chronic Hepatitis C Virus.
نویسندگان
چکیده
Background: Hepatitis C virus (HCV) may remain asymptomatic or cause liver fibrosis and cirrhosis. Objectives: We aimed to assess the relationship between serum peptidyl-prolyl cis-trans isomerase NIMA-interacted 1 (Pin1) levels due HCV. Methods: Serum samples of successive patients with HCV genotype 1b healthy volunteers were collected, Pin1 measured using ELISA kits. Liver stages calculated by Ishak Scoring System subdivided into two groups; stage < 3 (mild fibrosis) ≥ (advanced fibrosis). Correlation area under receiver operating characteristics (AUROC) analysis used investigate clinical histopathological properties infection. Results: Ninety-four 47 age- sex-matched included. The median age participants was 52, 55% whom females. mean (SD) level significantly higher in group compared (33.94 (21.15) vs. 26.82 (8.85) pg/mL, respectively, P = 0.007). Seventy-seven (82%) 17 (18%) showed mild advanced fibrosis, respectively. lower (29 (17.88) 43.59 (7.98) 0.001). found a positive correlation (r 0.71, cut off 33.04 pg/mL best sensitivity (100%) specificity (68.4%) (AUROC 0.81 [95% confidence interval: 0.72 - 0.90], 0.001) for distinguishing from fibrosis. Conclusions: be relevant marker predicting infected patients.
منابع مشابه
Peptidyl-prolyl cis/trans-Isomerase A1 (Pin1) Is a Target for Modification by Lipid Electrophiles
Oxidation of membrane phospholipids is associated with inflammation, neurodegenerative disease, and cancer. Oxyradical damage to phospholipids results in the production of reactive aldehydes that adduct proteins and modulate their function. 4-Hydroxynonenal (HNE), a common product of oxidative damage to lipids, adducts proteins at exposed Cys, His, or Lys residues. Here, we demonstrate that pep...
متن کاملRole of the peptidyl-prolyl cis/trans isomerase Pin1 in the ubiquitin proteasome system (UPS)
Wesentliche Teile dieser Arbeit sind in folgenden Publikationen veröffentlicht: Prolyl isomerase Pin1 acts as a switch to control the degree of substrate 14 3 Aim of this study 16 4 Results 17 4.1 The peptidyl-prolyl cis/trans isomerase Ess1 is an essential new player of the OLE pathway 17 4.1.1 Ess1 is a essential new player in the OLE pathway and functionally directly linked to Ole1 18 4.1.2 ...
متن کاملNovel spiroannulated 3-benzofuranones. Synthesis and inhibition of the human peptidyl prolyl cis/trans isomerase Pin1.
The novel 3H-spiro[1-benzofuran-2-cyclopentan]-3-one skeleton has been made accessible by different routes. One- and two-step protocols lead to tricyclic and tetracyclic benzofuranones 2 and 3, respectively. A four-step synthesis to spirocompound 4 is described. The novel spirocyclic benzofuranones display modest to no inhibition of the human peptidyl prolyl cis/trans isomerase Pin1.
متن کاملCytosolic Aryl sulfotransferase 4A1 interacts with the peptidyl prolyl cis-trans isomerase Pin1.
Sulfonation by cytosolic sulfotransferases plays an important role in the metabolism of both endogenous and exogenous compounds. Sulfotransferase 4A1 (SULT4A1) is a novel sulfotransferase found primarily in neurons in the brain. It is highly conserved between species, but no substantial enzyme activity has been identified for the protein. Consequently, little is known about the role of this enz...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Hepatitis Monthly
سال: 2021
ISSN: ['1735-3408', '1735-143X']
DOI: https://doi.org/10.5812/hepatmon.116687